Pttg1 transcription factor

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August undefined, 2024

WebFeb 24, 2024 · Multivariate analyses confirmed that PTTG1 expression was a factor of prognosis that is independent in terms of LUAD patients. Besides, PTTG1 methylation had a negative regulation on PTTG1, so PTTG1 had a high expressing level in LUAD tissues. ... (PTTG1), a ubiquitously expressed factor of transcription, is proven with the … WebWell known as a transcription factors, KLF10 was involved in the regulation of a variety of genes in different tissues [18-20]. PTTG1 was a potential target of KLF10 in cardiac hypertrophy [6,21] but their relationship in MM …

KLF10 inhibits cell growth by regulating PTTG1 in …

WebAug 12, 2015 · PTTG1 interacts with transcription factors including p53, Sp1, and upstream stimulatory factor 1 (USF1), which may induce additional genes involved in tumorigenesis and cancer development [20, 23, 24]. In terms of colorectal cancer, PTTG1 overexpression is associated with tumourigenesis, progression and cancer metastasis . WebResults show that PTTG1 exhibits properties of a global transcription factor, and specifically modulates the G1/S-phase transition by interacting with Sp1. Data show that … swearing higher intelligence

Transcriptional targets for pituitary tumor-transforming gene-1

WebThe encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) … WebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. Its overexpression occurs in a wide variety of human tumors including pituitary adenomas. Several factors and signalling pathways regulate pituitary PTTG1 expression, including estrogen, epidermal growth factor, octamer-binding transcription factor 1 and Rb/E2F1. WebOct 30, 2024 · Transcription factor SP1 was up-regulated in PDGF-BB-stimulated HAVSMCs, combined with PTTG1 promoter sequence and regulated PTTG1 expression, whose overexpression reversed the effects of PTTG1 interference on cell proliferation, migration and phenotypic switching. SP1 transcriptional activation of PTTG1 activated MAPK/ERK … skylark school wah cantt

petunia transcription factor, PhOBF1, regulates flower senescence …

Frontiers A Comprehensive Pan-Cancer Analysis for Pituitary …

WebOct 20, 2008 · She showed that PTTG1 protein binds to the c-myc promoter near the transcription start site and forms a complex with the ubiquitous transcription activator upstream stimulating factor 1 (USF1). Mapping of PTTG1 protein showed the region between amino acids 60 and 118 as the PTTG-DNA binding domain. WebMar 12, 2007 · The results show that PTTG1 exhibits properties of a global transcription factor, and specifically modulates the G1/S-phase transition by interacting with Sp1. This … swearing id robloxWebOct 30, 2024 · PTTG1 is also one of the inductive factors for the upregulated expression of pro-inflammatory TNF-α and oncogenic c-myc as well as the aggravated cell proliferation in hepatocellular carcinoma [9]. ... The promoter selective transcription factor SP1 regulates the expression of multiple genes and is involved in many cellular processes including ... skylarks charity twickenham

"WebJun 29, 2024 · Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer … " - Pttg1 transcription factor

Pttg1 transcription factor

Prognostic Significance of PTTG1 and Its Methylation in Lung

WebJan 28, 2015 · Background Pituitary tumor-transforming gene-1 (PTTG1) is a transcription factor that can affect transcriptional activity, angiogenesis, and cell senescence. We examined PTTG1 mRNA and protein expression in gastric cancer (GC) cell lines and tissues to determine its value as a biomarker for GC diagnosis and therapy. Methods PTTG1 … WebOct 30, 2024 · PTTG1 is also one of the inductive factors for the upregulated expression of pro-inflammatory TNF-α and oncogenic c-myc as well as the aggravated cell proliferation …

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Webthat PTTG1 acts as a global transcription factor, and speciﬁcally modulates the G1/S-phase transition by interactingwithSp1,whichmayunderlieitstransform-ingactivity. Results WebJul 28, 2024 · Overall, our findings indicate that PTTG1 is a glioma malignant factor that promotes angiogenesis, migration, invasion, and the evasion of apoptosis, and these roles …

WebFeb 1, 2024 · (A) Family analysis of transcription factors based on the RNA sequencing data; ( B ) Spearman analysis was used to detect the correlations between PCLAF and E2F1 and PTTG1 in the neuroblastoma ... WebAug 16, 2013 · The aberrant expression of proto-oncogenes is involved in processes that are responsible for cellular proliferation and the inhibition of myeloid differentiation in acute …

WebFeb 16, 2024 · Some up-regulated transcription factors during the flowering period of petunia were identified through transcriptional analyses and further functionally … WebPTTG1 has transcriptional activity and exerts its function either by directly binding to DNA or by interacting with other proteins such as other transcription factors [13]. PTTG1 overexpression ...

WebMar 27, 2024 · Keratinocyte growth factor (KGF) is a potent mitogen for epithelial cells, and it promotes survival of these cells under stress conditions. In a search for KGF-regulated …

WebJan 1, 2013 · Human pituitary tumor transforming gene 1 (PTTG1) is an oncogenic transcription factor that is overexpressed in many malignancies, especially cancers with metastatic potential, while transgelin-2 (TAGLN2) is an actin-binding protein shown to be a tumor suppressor. However, the expression and clinical significance of PTTG1 and … swearing imagesWebFIGURE 5 PTTG1 induces EMT via AKT signaling and Snail in breast cancer cells. A and B, transfection with siRNA targeting PTTG1 increased epithelial marker, E-cadherin, and … skylark security logoWebWe selected the lncRNA PTTG1-1:1, also identified as MIR3142HG or ENST00000517927, as the most upregulated lncRNA. ... SiRNA-mediated knockdown of p65/NF-kB further … skylark school of paraglidingWebInterestingly, transcription factors were significantly underrepresented among the differentially expressed genes, and only one transcription factor, Pttg1, showed significant differences between ... swearing iconWebJul 28, 2024 · Overall, our findings indicate that PTTG1 is a glioma malignant factor that promotes angiogenesis, migration, invasion, and the evasion of apoptosis, and these roles may be related to the TGF-β/PI3K-AKT-mTOR pathway. Thus, the targeted inhibition of PTTG1 might be a novel therapeutic strategy and a potential diagnostic biomarker for … skylark scarborough fishingWebAug 16, 2013 · The aberrant expression of proto-oncogenes is involved in processes that are responsible for cellular proliferation and the inhibition of myeloid differentiation in acute myeloid leukemia (AML). Pituitary Tumor-Transforming gene 1 (PTTG1), an oncogenic transcription factor, is abundantly expressed in various human cancers and … swearing in a relationshipWebThe increased proliferation of activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and excessive extracellular matrix (ECM)-protein pro swearing in advertising