The best-known subset of CD1d-dependent NKT cells expresses an invariant T-cell receptor (TCR) α chain. These are referred to as type I or invariant NKT cells (iNKT) cells. They are notable for their ability to respond rapidly to danger signals and pro-inflammatory cytokines. Once activated, they engage in effector functions, like NK transactivation, T cell activation and differentiation, B cell activation, dendritic cell activation and cross-presentation activity, and macrop… WebbAssessment in the following clinical contexts: HIV, primary immune deficiencies with NK cell defects, NK-cell lymphocytosis, solid-organ transplantation, immune reconstitution following bone marrow or hematopoietic cell transplantation This test is not useful for diagnosis or classification of NK cell malignancies.
Dissociation of NKT stimulation, cytokine induction, and …
Webb11 apr. 2024 · Abstract. During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC ... Webb1 nov. 2007 · The local NKT activation, local inflammation, and local infiltration of lymphocytes (CD4 + and CD8 + T cells as well as NK cells) may be required for the effects of this OX40L-DC therapy. In future studies, it would be interesting to ask whether this approach could be applied to treat metastatic disease. redhat spacewalk replacement
JP2024030210A - 炎症性病態の予防および治療 - Google Patents
WebbThis downregulation was shown in vitro to reduce NKT activation and IFNc secretion after aGalCer stimulation [79,80]. Hepatitis Murine NKT cells are highly enriched in the liver (comprising 10%–30% of T cells) [81,82], and murine models have clearly demonstrated a crucial role for NKT cell activation in mediating Webb22 juli 2024 · Activation of NKT cells is triggered by ligation of the semi-invariant TCR along with an array of co-stimulatory (CD28, CD40L, CD70, OX40, and 41BB) and co … Webb11 aug. 2024 · Administration of mRNA against SARS-CoV-2 has demonstrated sufficient efficacy, tolerability and clinical potential to disrupt the vaccination field. A multiple-arm, cohort randomized, mixed blind, placebo-controlled study was designed to investigate the in vivo expression of mRNA antibodies to immunosuppressed murine models to … riavviare spooler stampa windows 10